Why CBD in a Nasal Spray?

NeuroDiol™ Nasal Spray delivery has 8 times better absorption of CBD then any oral product especially into the nervous system and brain! Absorption is also much faster such that effects can be felt in a little as 3-5 minutes after dosing using our NeuroDiol™ Nasal Spray. Therefore you can take a much smaller dose for the same effects. Due to the high vascularity in the nasal passage, the CBD goes right into the bloodstream and quickly to the brain where many conditions have been shown in studies to best benefit.

Oral absorption of CBD, on the other hand, is inconsistent and slow.

When you take CBD pills or swallowed drops through the stomach, the active ingredient must pass through your liver before being absorbed. This is called the first pass effect. One of the main jobs of the liver is to break up and metabolize anything we eat or drink.  That slows down and diminishes orally administered CBD effects considerably, and requires much larger dosing. This is why NeuroDiol offers both Suppository and Nasal Sprays which both bypass the first pass effect. Try either of them once and you will be convinced it is much superior to oral CBD.

Supplement Facts

10-20 milliliter bottle-  1-4 Sprays in one or each nostril every 2-4 hours.             

Amount Per bottle                                                    % Daily Value

Water soluble Ulta Nano

Full Spectrum Hemp (Organic)                          250mg, 450mg

Terpenes: Lemonene.                                                *****

Myrcene, Linalool, Alpha & Beta Pinene                  *****

MCT  (Organic)                                                            *****

Potassium Sorbate, Glycerine.                                *****

*Daily Value not established

NeuroDiol™ Nasal Spray comes in strengths 250mg (4.2mg per spray) &  450mg (6.7mg per spray)

Testimonials

“I’m one of those guys who often takes oral supplements and notices next to nothing. That’s not uncommon. Digestion, pass through the liver, the acidic nature of the stomach and a host of other factors can keep you from properly absorbing precious molecules. But when I tried Dr. Lieurance’s nasal sprays and suppositories I noticed them almost immediately. I have now used them successfully for jet lag, inflammation and enhanced sleep and I’m completely enamored: these things are the real deal – and a valuable arsenal to any health hacker’s toolkit.”

Ben Greenfield

Research on CBD

CBD research under review:
Many studies on the impact of CBD, Hemp, Terpenes and cannabis historically have  employed small sample sizes, which limits the data researchers can gather and the conclusions they can draw from it. As the volume of these studies grows, though larger studies there will be more data to conduct review studies on the effects and efficacy of cannabis and its components, including CBD and Terpenes.

Rather than conducting a new experiment, review studies collate and compare the results of previously published, peer-reviewed studies. This allows authors to work with what is effectively a larger data set and more confidently answer questions about the subject.

Oral absorption of CBD, on the other hand, is inconsistent and slow.

Dosage and Use

Consult your health care provider before starting this or any other product on this site.

Dosage and Storage Instructions:  To start, we recommend 1-4 Sprays in one or each nostril every 2-4 hours.  Store in cool dry area.

Besides the health considerations, you can only smoke or vape in certain locations, whereas you can keep your NeuroDiol™ Nasal Spray handy anywhere you need it!

Transdermal applications in creams such as NeuroDiol™ Topical Cream  can be very  good to get a local CBD effect on a muscle, nerve, skin or an injury but this is not the best for a systemic effect. It can be best in many cases to mix and match different delivery methods together such as the NeuroDiol™ Topical Cream used with the NeuroDiol™ Nasal Spray or the NeuroDiol™ 2500mg Tincture can be taken then the NeuroDiol™ Nasal Spray used for break through pain or anxiety. Or NeuroDiol™  Suppository can be taken for sleep but if you wake up in the middle of the night and wish to get a fast dose of CBD you can then take the NeuroDiol™ Nasal Spray. Consider some of the NeuroDiol™ Combo Packages we offer.

Terpene Profile

Terpenes: These are the NON psychoactive components in cannabis. They are the fragrant essence of ALL essential oils! They give plants their unique smell and they also hold the healing benefits within the plants. Terpenes have been studied extensively and they are at the forefront of interest of the pharmaceutical companies due to the unique and safe profile they can have. Terpenes that are specifically shown to reduce pain, are anti inflammatory and reduce anxiety have been incorporated into NeuroDiol™.* These terpenes also have been shown to improve CBD and other cannabinoids utilization and uptake into the brain.*

Myrcene (or β-myrcene) is a terpene that occurs often in highly fragrant plants and herbs such as mangoes, hops, bay laurel leaves, thyme, lemongrass, and basil. Myrcene is produced by numerous cannabis strains, and some rodent-model studies have suggested that it might lend sedative effects. Main effects are Anti-inflammatory, Analgesic (pain relief), Antibiotic, Mood Elevation and Antimutagenic (anti cancer).*

Another place you’ll find myrcene is in mangoes. Anecdotal evidence suggests that eating a ripe mango prior to consuming cannabis may accentuate or extend the effects of cannabinoids; some have suggested that this is due to the fruit’s concentrations of myrcene, which is naturally synergistic with CBD and allows cannabinoids to more easily bridge the blood-brain barrier.

Linalool is a naturally occurring terpene found in many flowers and spices including lavender and coriander. It gives off a complex yet delicate floral aroma, and while its effects are myriad, it is in particular one of the substances used most widely to reduce stress. Humans have inhaled the scent of certain plants, including many containing linalool, since ancient times to help lower stress levels, fight inflammation, and combat depression.* Linalool has been the subject of many studies, including a recent one in which scientists allowed lab rats to inhale linalool while exposing them to stressful conditions. It was reported that linalool returned elevated stress levels in the immune system to near-normal conditions. Linalool’s Effects and Benefits include anti-anxiety, Antidepressant, Mood Elevation, Anti-inflammatory, Anti-epileptic and Analgesic.*

Limonene is an aromatic cannabis terpene produced in the flower’s resin glands. In isolation, it’s commonly associated with fruity and citrus aromas. Inhalation of limonene vapor increases serotonin and dopamine levels in key regions of the brain that are associated with anxiety, depression, and OCD. Limonene’s potential therapeutic benefits have shown potential in the following applications: Elevated mood*, Stress relief*, Antifungal properties*, Antibacterial properties*, May help relieve heartburn and gastric reflux*, Improves absorption of other terpenes and chemicals by way of the skin, mucous membranes, and digestive tract*

There’s also promising evidence for limonene’s anti-tumor effects. In lab rodents, limonene inhibited the growth of skin and mammary tumors. These studies were followed up with a Phase I human clinical trial which found that limonene was somewhat effective at reducing breast cancer tumor growth for nearly a year.* Later studies found that daily limonene supplementation for 2-6 weeks silenced a protein that promotes breast cancer tumor growth, suggesting that daily limonene consumption may inhibit the growth and spread of breast tumors.* Additional reports have revealed benefits of limonene in laboratory models of lung cancer and brain cancer by causing tumor cell death.* But like limonene’s benefits in breast cancer, high doses are likely needed beyond what may be present in cannabis alone.

Alpha & Beta Pinene, as you might have guess it, has a strong scent of pine. Commonly found in conifer trees, parsley, dill, basil, and rosemary, alpha-pinene is easy to detect. If a chemical profile of your cannabis strain is unavailable, just follow your nose. Popular strains with high alpha-pinene levels include Jack Herer, Blue Dream, and OG Kush. This powerful aromatic molecule doesn’t just smell great, it also contains many medicinal benefits.

Anti-Inflammatory

A study in 2012 showed that alpha-pinene was a potent anti-inflammatory agent against Acute Pancreatitis, an inflammatory disease with an unknown cause. A study in 2011 showed that alpha-pinene, along with all the different cannabinoids and terpenes found in cannabis, interact synergistically and amplify anti-inflammatory activity. These results show that alpha-pinene is helpful in inflammation management for diseases such as arthritis, Crohn’s, and multiple sclerosis.

Anti-Microbial

Both alpha-pinene and beta-pinene proved to be effective antimicrobial agents against bacterial and fungal cells. In 2011, alpha-pinene was tested as a potent treatment against a bronchitis virus that was previously hard to treat since antibiotics don’t work on viruses. Although not effective against all bacteria and viruses, alpha-pinene protects against a wide range of these infectious diseases. More studies need to be performed to assess the effectiveness of alpha-pinene on all bacteria.

Bronchodilator

Although one study claims that alpha-pinene exposure can cause upper respiratory irritation, the benefits far outweigh mild negative symptoms. In a 2011 study, alpha-pinene showed promise as a bronchodilator by opening up the upper respiratory tract (at low exposure levels) which can be helpful for people with asthma.

Memory

We’ve all heard of the forgetful stoner stereotype. The cannabinoid tetrahydrocannabinol (THC) plays a part in decreasing short-term memory attention. The alpha-pinene terpene, however, has been shown to counteract these memory impairing effects. Alpha-pinene plays a strong role in inhibiting acetylcholinesterase activity in the brain, which helps you retain memories more efficiently.

Citrus clementina

Pungent, refreshing, and sweet, Clementine terpenes supplies a variety of benefits, including its cleansing properties. Clementine’s citrus scent can improve and uplift your mood.

Clementine is a natural hybrid of mandarin and sweet orange. Clementine may boost the immune system, support metabolic function, and support gastrointestinal health.* It can help relieve occasional heartburn and indigestion.* Clementine terpene is versatile as it may aid healthy respiratory function as well.*

Aromatic benefits of Clementine include elevation of mood and positive emotions.  Citrus oils, including Clementine, can also help you feel more invigorated and less anxious. Not only does diffusing Clementine lift your emotions, it also purifies and cleanses the air. Enhance your general health by adding Clementine to your wellness routine.

Disclosures, COA's & Lab Testing

GlutaGenic does not sell or distribute any products that are in violation of the United States Controlled Substances Act (USA CDA). The company does sell and distribute hemp-based products.

FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE

The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent disease or medical conditions. The products and information found on GlutaGenic.com are not intended to replace professional medical advice or treatment. Individual results may vary. GlutaGenic urges you to seek the advice of a qualified professional for any health concern, and to share with your provider any information pertaining to your health and well-being, including the use of supplemental nutrition. We try our best not to make mistakes; however, if typographical errors appear in our site, we cannot be held responsible. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other complications before using any product. The Federal Food, Drug, and Cosmetic Act require this notice.

COA’s and Lab Testing