NeuroDiol™ Suppositories are made using full spectrum hemp extract from an organic Hawaiian grown, high CBD strain. We added terpenes, our probiotic blend APO-19™ and (SRT™) slow release technology, for the world’s finest Hemp Suppository line.
Rectal administration of CBD and other cannabinoids allows your body to absorb considerably more than orally. By bypassing the destructive acids in the stomach, digestive enzymes and liver filter the NeuroDiol™ into your bloodstream through the rectal wall.
NeuroDiol™ Suppositories are an excellent way to deliver CBD close to problem areas in the rectal region such as large intestines, prostate, vagina and uterus.
NeuroDiol™ Suppositories may be superior to oral or inhalation!
There are many benefits to rectal administration of Hemp/ CBD, even when compared to other methods of Hemp/CBD administration. In cases of surgery, illness or injury, oral methods may not be an option due to vomiting, gastrointestinal difficulties, or physical limitations of the mouth or throat. Oral administration of Hemp/CBD undergoes degradation in the gastrointestinal tract, and is metabolized by the liver before circulating into the blood stream. Suppositories are able to bypass these issues, and deliver the Hemp/CBD into your body more efficiently, for a longer sustained effect.
NeuroDiol™ Suppositories allow for faster absorption with initial effects felt in as little as 10-15 minutes after administration, and last for 4-8 hours. Due to the speed of onset and consistency of effect, Hemp/CBD suppositories are a reliable and superior route for administration for many people.
For initial dosing, NeuroDiol™ Suppositories should be taken at home and one should not drive after taking it until you know how, your unique self, reacts with Neurodiol™. Effects are typically a mildly relaxed state.
Testimonials
Testimonials
“I’m one of those guys who often takes oral supplements and notices next to nothing. That’s not uncommon. Digestion, pass through the liver, the acidic nature of the stomach and a host of other factors can keep you from properly absorbing precious molecules. But when I tried Dr. Lieurance’s nasal sprays and suppositories I noticed them almost immediately. I have now used them successfully for jet lag, inflammation and enhanced sleep and I’m completely enamored: these things are the real deal – and a valuable arsenal to any health hacker’s toolkit.”
Ben Greenfield
Supplement Facts
Supplement Facts
Dosage and Storage Instructions: Wash your hands thoroughly with soap and water. Keep the suppository in the refrigerator so it remains hard before removing the wrapper. Put on a finger cot or disposable glove, if desired (available at a pharmacy). Lubricate the suppository with a water soluble lubricant such as K-Y Jelly or coconut oil, not petroleum jelly (Vaseline). If you do not have this lubricant, moisten your rectal area with cool tap water. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Insert the suppository, pointed end first, with your finger until it passes the muscular sphincter of the rectum, about ½ to 1 inch in infants and 1 inch in adults (If not inserted past this sphincter, the suppository may pop out). Hold buttocks together for a few seconds. Remain lying down for about 5 minutes to avoid having the suppository come out. Discard used materials and wash your hands thoroughly.
Suggested dosage is 1 (one) suppository daily. Depending on your daily schedule, it is recommended that you insert the suppository prior to bed.
DO NOT DRIVE OR OPERATE MACHINERY AFTER CONSUMING THIS PRODUCT.
Product is not intended for oral usage.
Store this product in a refrigerated climate. Keep this product away from sunlight. Please use the product within six months of purchase date for best results.
Supplement Facts
Serving size: 1 Servings: 10
Amount Per Piece % Daily Value
Hemp/CBD Extract 50, 125, 300, 600mg
Terpenes: Myrcene, Linalool, Limonene *****
AP0-19™ Probiotic Blend *****
SRT™ Polysaccharide Complex. *****
Daily Value not established
Tips and Tricks
Tips and Tricks
Transdermal applications in creams such as NeuroDiol™ Deep Penetrating Blue Creamcan be very good to get a local CBD effect on a muscle, nerve, skin or an injury, however this is not the best for a systemic effect. It can be best in many cases to mix and match different delivery methods together such as the NeuroDiol™ Deep Penetrating Blue Cream used with the NeuroDiol™ Nasal Mist or NeuroDiol™ Tincture’s can be taken with the NeuroDiol™ Nasal Mist, for breakthrough pain or anxiety. NeuroDiol™ Suppositories can be taken for sleep, and if you wake up in the middle of the night and wish to get a fast dose of CBD, you can then take the NeuroDiol™ Nasal Spray. Our NeuroDiol™ Suppositories offers a great advantage for a slow release of CBD such as with flying (See Travel Hacker Kit).
NeuroDiol™ Tincture’s includes terpenes and MCT oil for better absorption than any other CBD tincture on the market. NeuroDiol™ offers Deep Penetrating BlueCream, Suppositories and a Nasal Mist, which all bypass the first pass liver effect for faster onsets.
For a systemic effect, vaping and smoking CBD is a rapid way to deliver CBD, however there are negative health effects. Our NeuroDiol™ Tincture is a much better option than vaping and smoking. If a rapid onset is desired, the NeuroDiol™ Nasal Mist works great, and both the NeuroDiol™ Tincture and NeuroDiol™ Nasal Mist can be used together.
Consider some of the NeuroDiol™ Combo Packages we offer.
Why Suppositories?
Why Suppositories?
Why Suppositories makes Sense.
Many people are uneasy with even mentioning of rectal suppositories, until they realize how very powerful this approach can prove to be. For some, navigating around this phobia could make the difference between health and sickness, or enhanced performance for those biohackers!
There is growing acknowledgement of the need to provide safer, more cost-effective treatments that can either reduce the need for pharmaceuticals (ie: drugs) and/or to reduce their side effects. There is a mountain of research to demonstrate vitamins, extracts, nutrients, herbals and nutraceuticals can do just that, if only they could be absorbed in such a manner as to allow greater therapeutic effect.
How do Rectal Suppositories Work?
Everything, when administered orally, is absorbed from the gastrointestinal tract into the portal venous circulation and passes through the liver (first pass metabolism), where the process of metabolism or breakdown begins. Suppositories, like intravenous (IV), intramuscular (IM), and transdermal methods of administration, bypass this “first pass” effect and are absorbed into the rectal veins without encountering liver metabolism. Fortunately, the rectum is filled with blood vessels that offer direct access into the body’s bloodstream. This allows for rapid access to systemic circulation.
When nutrients are put into our special suppository base they are protected and delivered through Slow Release Technology, along with the support of the probiotics APO-808. Glutagenic’s™ proprietary suppository base is formulated with ingredients that promote the movement of the active nutrients from the base to the rectum.This technology facilitates solubility, and allows a compound that is usually insoluble in water (hydrophobic) to dissolve, and thus be absorbed. This is crucial for poorly absorbed compounds.
ABC’s suppositories are easy to insert, non-irritating, rapid-melting, fully absorbed in 5-10 minutes, and you’ll not know its in there after insertion.
Terpenes
Terpenes
Terpenes: These are the NON psychoactive components in cannabis. They are the fragrant essence of ALL essential oils! They give plants their unique smell and they also hold the healing benefits within the plants. Terpenes have been studied extensively, and they are at the forefront of interest of the pharmaceutical companies, due to the unique and safe profile they can have. Terpenes that are specifically shown to reduce pain, are anti-inflammatory and reduce anxiety, have been incorporated into NeuroDiol™.* These terpenes also have been shown to improve CBD and other cannabinoids utilization and uptake into the brain.*
Myrcene: is a terpene that occurs often in highly fragrant plants and herbs such as mangoes, hops, bay laurel leaves, thyme, lemongrass, and basil. Myrcene is produced by numerous cannabis strains, and some rodent-model studies have suggested that it might lend sedative effects. Main effects are Anti-inflammatory, Analgesic (pain relief), Antibiotic and Mood Elevation.*
Another place you’ll find myrcene is in mangoes. Anecdotal evidence suggests that eating a ripe mango prior to consuming cannabis may accentuate or extend the effects of cannabinoids; some have suggested that this is due to the fruit’s concentrations of myrcene, which is naturally synergistic with CBD and allows cannabinoids to more easily bridge the blood-brain barrier.
Limonene: is an aromatic cannabis terpene produced in the flower’s resin glands. In isolation, it’s commonly associated with fruity and citrus aromas. Inhalation of limonene vapor increases serotonin and dopamine levels in key regions of the brain, that are associated with anxiety, depression, and OCD. Limonene’s potential therapeutic benefits have shown potential in the following applications: Elevated mood*, Stress relief*, Antifungal properties*, Antibacterial properties*, May help relieve heartburn and gastric reflux*, Improves absorption of other terpenes and chemicals by way of the skin, mucous membranes, and digestive tract* (Ref)
Alpha & Beta Pinene, as you might have guess it, has a strong scent of pine. Commonly found in conifer trees, parsley, dill, basil, and rosemary, alpha-pinene is easy to detect.
A study in 2012, showed that alpha-pinene was a potent anti-inflammatory agent against Acute Pancreatitis, an inflammatory disease with an unknown cause. A study in 2011 showed that alpha-pinene, along with all the different cannabinoids and terpenes found in cannabis, interact synergistically and amplify anti-inflammatory activity. These results show that alpha-pinene support lower inflammation management for diseases such as arthritis, Crohn’s, and multiple sclerosis.*
Both alpha-pinene and beta-pinene proved to be effective antimicrobial agents against bacterial and fungal cells. In 2011, alpha-pinene was tested as a potent treatment against a bronchitis virus that was previously hard to treat since antibiotics don’t work on viruses. Although not effective against all bacteria and viruses, alpha-pinene was shown in research to support the immune system with a wide range of these infectious diseases. More studies need to be performed to assess the effectiveness of alpha-pinene on all bacteria. (Ref)
Bronchodilator: In a 2011 study, alpha-pinene showed promise as a bronchodilator by opening up the upper respiratory tract (at low exposure levels) which can be helpful for people with asthma.
Memory: We’ve all heard of the forgetful stoner stereotype. The cannabinoid tetrahydrocannabinol (THC) plays a part in decreasing short-term memory attention. The alpha-pinene terpene, however, has been shown to counteract these memory impairing effects. Alpha-pinene plays a strong role in inhibiting acetylcholinesterase activity in the brain, which helps you retain memories more efficiently. (Ref)
Alpha Phellandrene: This terpene smells herbaceous, citrusy, minty, peppery, and a little woodsy. The next time you smell mint leaves or a lavender candle, appreciate the Alpha Phellandrene terpene smell!
Anti-depressive & Analgesic Actions of limonene, α-Phellandrene, and in a Neuropathic Pain Model (Ref)
Alpha–phellandrene significantly inhibited the production of the pro-inflammatory cytokines TNF-α and IL-6. Alpha–phellandrene Promotes Immune Responses in Normal Mice Through Enhancing Macrophage Phagocytosis and Natural Killer Cell Activities. (Ref)
Alpha–phellandrene has modulating effect on neutrophil migration and mast cell degranulation processes. (Ref)
Boswellia: or Indian frankincense, is a resin herbal extract from the boswellia tree, which natural medicine practices have used for centuries. Its anti-inflammatory effects mean that it may help with inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and asthma. We included this amazing extract into our products due to all of the positive healing properties
Linalool: is a naturally occurring terpene found in many flowers and spices including lavender and coriander. It gives off a complex yet delicate floral aroma, and while its effects are myriad, it is in particular one of the substances used most widely to reduce stress. Humans have inhaled the scent of certain plants, including many containing linalool, since ancient times to help lower stress levels, fight inflammation, and combat depression.* Linalool has been the subject of many studies, including a recent one in which scientists allowed lab rats to inhale linalool while exposing them to stressful conditions. It was reported that linalool returned elevated stress levels in the immune system to near-normal conditions. Linalool’s Effects and Benefits include anti-anxiety, Antidepressant, Mood Elevation, Anti-inflammatory, Anti-epileptic and Analgesic.* (Ref)
Our Technology
Our Technology
Sustained-release technology in ABC’s suppositories are of benefit, due to increased bioavailability. ABC has found that the addition of SRT improved the bioavailability of glutathione by 30% compared to the suppositories without SRT. These absorptions were improved enormously by the addition of a proprietary and natural polypeptide. Excellent prolonged absorption and high bioavailability were obtained exhibiting both high plasma level and prolonged absorption. Our research shows that ABC’s preparations containing SRT may be superior in a rectal preparation, with prolonged action giving a high plasma level, compared to standard suppository bases without ABC’s SRT!
Why do we use probiotics in our suppositories?
APO-808 is a proprietary blend of probiotic strains that is unique to our suppository technology. ABC has discovered that certain bacteria strain combination of probiotics can support the absorption and utilization when combined with various ingredients. Probiotics are beneficial bacteria that exist in our large intestine called the microbiome, which is exactly where the suppository is absorbed. Using probiotics via suppository makes for a unique route of delivery, as it bypasses the acid in the stomach that normally destroys most probiotics taken orally. In addition, it has been clinically shown that oral probiotics may not even colonize your gut at all. Due to the need for probiotics to be incorporated into the gut wall, research has shown we might be wasting our money taking most probiotics orally. ABC’s probiotic strains have been combined with our special suppository base, which consists of organic palm oil. This combination rests on the gut wall over a 5-8 hour period, to allow for the incorporation and colonization of the bacteria in the large intestines. Besides the unique delivery of the probiotics via suppository route, it has been scientifically shown that many nutrients are brought into the bloodstream by various strains of beneficial flora in your microbiome. The scientists at ABC have isolated various combination of flora that work specifically with the nutrients it is combined with.
APO-808 is designed to work with in CBD to down regulate the inflammation through normalizing the gut microbiome as well as allowing maximum absorption of CBD. The strains contained in the APO-808 Blend, have been shown in research to help support healthy inflammation and immune function.
Disclaimer, COA's & Lab Testing
Disclaimer, COA's & Lab Testing
Advanced Biome Corp does not sell or distribute any products that are in violation of the United States Controlled Substances Act (USA CDA). The company does sell and distribute hemp-based products.
FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE
The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent disease or medical conditions. The products and information found on AdvancedBiomeCorp.com are not intended to replace professional medical advice or treatment. Individual results may vary. Advanced Biome Corp urges you to seek the advice of a qualified professional for any health concern, and to share with your provider any information pertaining to your health and well-being, including the use of supplemental nutrition. We try our best not to make mistakes; however, if typographical errors appear in our site, we cannot be held responsible. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other complications before using any product. The Federal Food, Drug, and Cosmetic Act require this notice
MethylMax™ is a revolutionary product containing the most advanced methylator's combined in one suppository product. We use the highest quality, top of the line ingredients, with a slow release technology & our APO-808 probiotic strain for maximum absorption. You will not find this comprehensive of an ingredient list anywhere. Co-Designed by Dr. Daniel Pompa and Dr. John Lieurance, for maximum support for detoxification pathways and hormone detox, as well as brain and neurological support. Try one for yourself and feel the dramatic difference in both the methylation ingredients, along with superior suppository delivery, compared to other products. You'll know that we have created something very special with MethylMax™.
Each order of MethylMax™ contains 15 suppositories. Consult your health care practitioner before using this or any of MitoZen's product line.
SandMan Ultra™ is an oral Ultra Nano Liposomal liquid product. Learn about Liposomal here. Each 15ml contains 255mg of glutathione, 210mg of Melatonin, Terpenes and CBD from water soluble, whole plant full spectrum hemp extract NeuroHEMP™. The body’s most powerful anti-oxidant (Glutathione) is combined with the brains primary anti-oxidant, melatonin. This is the most advanced and strongest sleep support, with a slow release over a 5-7 hour period, to support sleep all night long due to our proprietary slow release technology using SRT ™ Polysaccharide Complex. Deep sleep has been shown clinically to support the break down of amyloid beta protein tangles. Another important and recent finding in science of sleep, is that deep sleep cleanses the brain. The waste removal system of the brain, the glymphatic system, is at its most efficient during deep sleep. A recent international study shows it may be possible that getting too little deep sleep prevents glymphatic clearance and can cause neurological diseases. Basically, your neurons will be swimming in their own excrement without adequate deep sleep.
Contains 30 ml of GlutaStat™ for Intranasal (or Nebulized) Application. This is a flagship anti microbial product for upper respiratory and sinus health. This works remarkably well as a nasal spray as well as for nebulizing. This product is commonly nebulized by direction of health care practitioner. See Nebulizer option here.
Excellent for chronic sinusitis, bronchitis, and any upper respiratory disorders.
Reduction of rhinorrhea, hyper lacrimation, sneezing, and bronchospasm.
High potency formula results in sustained-release Glutathione for optimal blood levels.
Anti-Microbial Herbal Extracts Wild Crafted Oregano, Sage, Bay Leaves and Clove, Copaiba
Silver Hydrosol (Ag (n)+1) exclusively available from GlutaGenics!
N-acetylcysteine (NAC) exclusively available from GlutaGenics!
This product was designed to provide optimal support for upper respiratory tract (Sinus’/Lungs)
Sold in 30 ml Multi dose bottle and Bulk 120ml Bottle.
*Should be kept refrigerated to maintain full potency
See our top quality nebulizer with the portability and ease of use for a busy lifestyle. The applications are impressive and this machine works very well with Glutathione and Glutagenics products! Everything you need comes with the box such as charger, and dust cover.
CONSIDER A BULK 120ml bottle GLUTASTAT FOR LONGER PROTOCOLS OR FOR YOUR ENTIRE FAMILY TO USE.
PLEASE SCHEDULE A $69 VIRTUAL APPOINTMENT WITH OUR DOCTOR FOR A PRESCRIPTION IN ORDER TO PURCHASE A NEBULIZER OR IF YOU HAVE A NEED FOR DIRECTION WITH PRODUCT USE.
*Should be kept refrigerated to maintain full potency
SandMan™contains 250mg of glutathione, 200mg of Melatonin, Terpenes, Proprietary blend of SandMan Complex™ (CBD from whole plant hemp extract and magnolia) along with our proprietary AP0-808™ probiotic strain, the body’s most powerful anti-oxidant (Glutathione) is combined with the brains primary anti-oxidant (melatonin) along with SandMan Complex™ for neurotransmitter support for GABA to aid in deep relaxation. This is the most advanced and strongest Sleep support, with a slow release over a 5-7 hour period to support sleep all night long, due to our proprietary slow release technology using SRT ™ Polysaccharide Complex. Deep sleep has been shown clinically to support the break down of amyloid beta protein tangles. Another important and recent finding in science of sleep is that Deep sleep cleanses the brain. The waste removal system of the brain, the glymphatic system, is at its most efficient during deep sleep. A recent international study shows it may be possible that getting too little deep sleep prevents glymphatic clearance and can cause neurological diseases. Basically your neurons will be swimming in their own excrement without adequate deep sleep.
This product utilizes a unique approach to health and healing using super high physiologic melatonin supplementation. See this article on Melatonin.
Ultimate Sleep Combo Details: Our 2 most powerful Sleep products, so you can experiment with a combination, and find out which one works best your you! "When I really need a good night sleep, I take a 300mg NeuroDiol and a Sandman together, and my Oura Ring scores are in the 90's!" Ben Greenfield
Sleep Quality is the Holy Grail for a Happy & Healthy Life!
When would you want to activate mTOR? When muscle, tissue, ligament, tendon or cartilage growth is desired to be turned on. When mTOR is activated, stem cells will grow and proliferate stronger and faster. Therefore, this is a powerful product to take after a surgery, or any regenerative therapy like PRP, prolotherapy, stem cell injections or any injury, for faster recovery. Someone also might consider more mTOR activity helpful during exercise, such as a race or workout. If you're a professional and looking for more endurance mentally and physically throughout the day, this is the product for you.
The reality with mTOR. You want to balance your mTOR. It's important not to always be activating mTOR, and too much inhibitor of mTOR won't let you heal and repair physically. That's why we suggest that you might use intermittent fasting for best results with this product. An 8-10 hour feeding window is advised, along with an Eating Restricted Diet. This gives you a strong inhibition to mTOR.
Serene™ 30 ml bottle, is the newest and most exciting product at MitoZen. We have worked hard to source the most potent plants in order to make our whole plant full spectrum hemp extraction. NeuroHEMP™ is our UltraNano, Water Soluble, Full Spectrum Hemp Delivery System with rapid onset. Chicken flavor makes this taste great for your cat or dog. Product provides a full 25mg/mil. Add to your pets food or drink, or put into any toy to dose your pet. Numerous studies support the full spectrum hemp extraction over the isolated CBD products for effectiveness. Besides the natural terpenes maintained through careful processing, Serene™ has an added terpene profile which makes it advanced enough to support absorption and effectiveness of the CBD and other cannabinoids. Terpenes found in cannabis and hemp have been studied by the medical establishment for their healing powers, and synergistic effects, called the entourage effect. This is the effect in your body, through various combinations of the cannabinoids, along with these terpenes. This product is made from organic hemp grown in a high altitude farm on the big island of Hawaii, where the volcanic soil is rich in minerals. The strain used in this product, contains super high CBD levels and the legal amount of THC, along with the rich family of cannabinoids and terpenes in these special hemp plants grown with love and kindness. Please consult your healthcare provider regarding use and dosage of this product.
ZEN Nasal Spray™ is our strongest formula, and is made from different medicinal plants from the Amazon, to calm and quiet the mind, as well as to reduce anxiety and stress. ZEN EO Nasal Spray™ is made with Ultra Nano Liposomal terpenes & essential oils. ZEN CBD Nasal Spray™ contains essential oils, terpenes and full spectrum NeuroHEMP™. The Zen formulas are powerful in the ability to calm the mind and allow for maximum vagal activation (stimulation of the vagal nerve). You will experience an afterglow effect, following the initial temporary burning feeling after administration. See this article about vagus stimulation by my friend Ben Greenfield here.Also see Ben Greenfield latest article on meditation hacks here. When activated, the Vagus works to balance the autonomic nervous system. It’s an effect that mimics meditation, breath work and sauna/cold exposure. For those who have done sauna rounds with cold and hot, you will know how calm one feels. Improved vagus function increases the brain blood flow, and affects the release of several stimulatory neurotransmitter leading to positive effects. The use of ZEN Nasal Spray™ is becoming more popular around the world, as people are becoming more aware of this amazing product! ZEN Nasal Spray™ can be ordered in a 30 ml bulk bottle (includes nasal spray bottle). Please choose cold shipping, at check out, for the oxytocin version of ZEN for potency preservation. Get 23% off if you buy our 4 pack options!
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Strictly Necessary Cookies
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.
Reviews
There are no reviews yet.