Testimonials

“I’m one of those guys who often takes oral supplements and notices next to nothing. That’s not uncommon. Digestion, pass through the liver, the acidic nature of the stomach and a host of other factors can keep you from properly absorbing precious molecules. But when I tried Dr. Lieurance’s nasal sprays and suppositories I noticed them almost immediately. I have now used them successfully for jet lag, inflammation and enhanced sleep and I’m completely enamored: these things are the real deal – and a valuable arsenal to any health hacker’s toolkit.”

Ben Greenfield

Supplement Facts

Supplement Facts: NeuroNAD™ Suppository

Serving size: 1                                                      Servings: 10

Amount Per Piece                                                  % Daily Value

Pure NAD+ Nicotinamide Adenine Dinucleotide.     500mg

Proprietary Blend: Fisetin, Ginkgo Biloba,                      *****

EGCG, Lutein, Quercetin, Curcumin,                                *****

Resveratrol                                                                                  *****

Trimethyl Glycine (TMG)                                                       ***** 

Terpene profile: Alpha Pinene,                                           *****

Beta Pinene, Delta 3 Carene,                                               *****

Alpha Phellandrene.                                                               *****

AP0-808 Probiotic Blend                                                      *****

SRT Polysaccharide Complex.                                             *****

Organic Palm Oil                                                                       *****

*Daily Value not established

Supplement Facts: NeuroNAD™ Nasal Mist

20 milliliters bottle / Bulk Bottle 120ml

Contains 60 sprays per 20 ml bottle

Proprietary Blend
__________________________________________________

Pure NAD+ Nicotinamide Adenine Dinucleotide      2g/ml

Bio Ocean minerals                                                             *mg/ml

Terpenes: Eucalyptol.                                                        *mg/ml

Saline                                                                                       *mg/ml

Glycerine                                                                                 *mg/ml

Potassium Sorbate                                                               *mg/ml

*Daily Value not established

NeuroNAD™  Nasal Mist

NeuroNAD™ Nasal Spray contains 2 grams of NAD+. ABC & Glutagenic have combined forces to bring you the finest and highest potency NAD+ along with Bio-Ocean mineral water. What is NAD? Nicotinamide Adenine Dinucleotide (NAD) is a metabolic co-enzyme that structures, repairs, and is an essential component of energy production (mitochondrial function); heavily involved in DNA repair and cell repair; responsible for turning certain genes on and off; and essential for maintaining neurotransmitter levels, for the proper functioning of the brain. Multiple studies on NAD+ have been done and currently ongoing, for its critical step in the production of energy at the cellular level (ATP production in the mitochondria). NeuroNAD™ is a powerful way to provide NAD+ to supplement as levels decline with age. Using Nasal Spray Enhancing Technology which is a technology to hold medicine to the mucous membrane longer than other nasal spray to allow better absorption of our nutrients.

Nasal delivery bypasses the GI tract and delivers NAD+ directly to the bloodstream. Also see NeuroNAD™ Suppository.

Explore the incredible benefits of NeuroNAD™ Nasal Spray on neurons rescued and repair by using  intranasal NAD+.

• Rescue Neurons from death by NAD+ starvation caused by Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, frontotemporal dementia or amyotrophic lateral sclerosis
• Reduce brain damage 86% even when administered 2 hrs after loss of blood flow
• Restore NAD+ levels in hippocampus far more effectively than Injection

The 2 Organs that require the most NAD+ and are also the most sensitive to low levels, are the Heart and Brain. The magic of the combination program using both NeuroNAD™ Suppository & NeuroNAD™ Nasal Spray is very special.  The NeuroNAD™ Suppository supplies NAD+ directly into the Heart via the rectum’s venous drainage and NeuroNAD™ Nasal Spray directly into the brain!  The Science is very special! Try them yourself and feel the difference.

Take a close look at Micro Glial activation, as well as Cellular Senescence to fully appreciate NeuroNAD™ Suppositories.

Choose Combo package for the x10 NeuroNAD™ Suppositories and the x1 NeuroNAD™ Nasal Spray together. 

Tips & Tricks

1. 3-5 days a week take NeuroNAD™ suppository in the morning upon waking. (Best if practicing intermittent fasting & skipping breakfast, but not necessary) .
2. Use NeuroNAD™ Nasal Spray 2-3 times a day using 2 sprays each nostril. (The Nasal Spray can also be done fasting or feeding)
3. ResveraCel– 1 capsule 2 times a day. ResveraCel is a precursor to NAD+ called Nicotinamide riboside (NR).

Research on NAD+

Dr John Lieurance with Dr. Mestayer at the 2015 NAD+ Summit. Dr. Mestayer is considered the leading authority in the USA on intravenous NAD infusions.

What is NAD?

Nicotinamide Adenine Dinucleotide (NAD) is a metabolic co-enzyme that structures, repairs, and is an essential component of energy production (mitochondrial function); heavily involved in DNA repair and cell repair; responsible for turning certain genes on and off; and essential for maintaining neurotransmitter levels, for the proper functioning of the brain.

Why Is it Important?

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NAD+, or nicotinamide adenine dinucleotide, is a critical coenzyme found in every cell in your body, and it’s involved in hundreds of metabolic processes. But NAD+ levels decline with age. NAD+ has two general sets of reactions in the human body: helping turn nutrients into energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions. These processes are incredibly important.

How NAD+ Is Powerful

Open any biology textbook and you’ll learn about NAD+, which stands for nicotinamide adenine dinucleotide. It’s a critical coenzyme found in every cell in your body that’s involved in hundreds of metabolic processes like cellular energy and mitochondrial health. NAD+ is hard at work in the cells of humans and other mammals, yeast and bacteria, even plants.

Scientists have known about NAD+ since it was first discovered in 1906, and since then our understanding of its importance has continued to evolve. For example, the NAD+ precursor niacin played a role in mitigating pellagra, a fatal disease that plagued the American south in the 1900s. Scientists at the time identified that milk and yeast, which both contain NAD+ precursors, alleviated symptoms. Over time scientists have identified several NAD+ precursors — including nicotinic acid, nicotinamide, and nicotinamide riboside, among others — which make use of natural pathways that lead to NAD+. Think of NAD+ precursors as different routes you can take to get to a destination. All the pathways get you to the same place but by different modes of transportation.

Recently, NAD+ has become a prized molecule in scientific research because of its central role in biological functions. The scientific community has been researching how NAD+ relates to notable benefits in animals that continue to inspire researchers to translate these findings to humans. So how exactly does NAD+ play such an important role? In short, it’s a coenzyme or “helper” molecule, binding to other enzymes to help cause reactions on the molecular level. But the body doesn’t have an endless supply of NAD+. In fact, it actually declines with age.

The history of NAD+ research, and its recent establishment in the science community, has opened the floodgates for scientists to investigate maintaining NAD+ levels and getting more NAD+.

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What is the History of NAD+?

NAD+ was first identified Sir Arthur Harden and William John Young in 1906 when the two aimed to better understand fermentation — in which yeast metabolize sugar and create alcohol and CO2. It took nearly 20 years for more NAD+ recognition, when Harden shared the 1929 Nobel Prize in Chemistry with Hans von Euler-Chelpin for their work on fermentation. Euler-Chelpin identified that the structure of NAD+ is made up of two nucleotides, the building blocks for nucleic acids, which make up DNA. The finding that fermentation, a metabolic process, relied on NAD+ foreshadowed what we now know about NAD+ playing a critical role in metabolic processes in humans.

Euler-Chelpin, in his 1930 Nobel Prize speech, referred to NAD+ as cozymase, what it was once called, touting its vitality. “The reason for our doing so much work on the purification and determination of the constitution of this substance,” he said, “is that cozymase is one of the most widespread and biologically most important activators within the plant and animal world.”

Otto Heinrich Warburg — known for “the Warburg effect” — pushed the science forward in the 1930s, with research further explaining NAD+ playing a role in metabolic reactions. In 1931, the chemists Conrad A. Elvehjem and C.K. Koehn identified that nicotinic acid, a precursor to NAD+, was the mitigating factor in pellagra. United States Public Health Service Doctor, Joseph Goldberger, had previously identified that the fatal disease was connected to something missing in the diet, which he then called PPF for “pellagra preventive factor.” Goldberger died before the ultimate discovery that it was nicotinic acid, but his contributions led to the discovery, which also informed eventual legislation mandating the fortification of flours and rice on an international scale.

The next decade, Arthur Kornberg, who later won the Nobel Prize for showing how DNA and RNA are formed, discovered NAD synthetase, the enzyme that makes NAD+. This research marked the beginning of understanding the building blocks of NAD+. In 1958, the scientists Jack Preiss and Philip Handler, defined what’s now known as the Preiss-Handler pathway. The pathway shows how nicotinic acid — the same form of vitamin B3 that helped cure pellagra — becomes NAD+. This helped scientists further understand the role of NAD+ in the diet. Handler later earned the National Medal of Science from President Ronald Reagan, who cited Handler’s “outstanding contributions to biomedical research…furthering the state of American science.”

While scientists had now realized the importance of NAD+, they had yet to discover its intricate impact on a cellular level. Forthcoming technologies in scientific research, combined with comprehensive recognition of the coenzyme’s importance, ultimately encouraged scientists to continue studying the molecule.

The Nuance of NAD+

Our current understanding of the importance of NAD+ really began in the 1960s. Using nuclear extracts from hen liver, French scientist Pierre Chambon identified a process called Poly ADP-ribosylation, where NAD+ is broken down into two component parts, one of which (nicotinamide) gets recycled, while the other (ADP-ribose) meets up with a protein. This research formed the foundation of the field of PARPs, or poly (ADP-ribose) polymerases, a group of proteins that rely on NAD+ to function and perform cellular functions. PARPs are similar to another group of proteins called sirtuins, in that they both only function in the presence of NAD+.

Scientists often refer to sirtuins as “guardians of the genome” for their role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. Sirtuins are a group of proteins that were first discovered in the 1970s, but their dependence on NAD+ wasn’t realized until the 1990s. MIT biologist Leonard Guarente identified that SIR2, a sirtuin in yeast, extended the life of the yeast only when it was activated by NAD+.

“Without NAD+, SIR2 does nothing. That was the critical finding on the arc of sirtuin biology,” Guarente said.

Knowing this created a clear link between sirtuins and metabolism. It also clued scientists in on a crosstalk between biological functions, i.e., that metabolism is intricately related to other biological processes. Additionally, it inspired more research on a topic previously overlooked.

“There are maybe 12,000 papers on sirtuins now. At the time we discovered the NAD+ dependent deacetylase activity, the number of papers was in the 100s,” Guarante’s said.

Humans get NAD+ from their diet via foods, however NAD+ is not absorbed orally, and must be taken as an IV or Nasal Spray, such as with NeuroNAD™ Nasal Spray.

Dr. Lieurance worked toward creating a better NAD+ delivery.  Shortly after pioneering the Nasal Delivery in 2018, he began working on way to make NAD+ stable in a suppository, and NeuroNAD™ Suppository was born. NeuroNAD™ Suppository combines ABC’s SRT™ Slow Release Technology along with Nano Lipospheric Technology NLT NAD+™.  Both NeuroNAD™ products are a highly efficient way to boost NAD+ into the body, and can be used together for maximum effect to raise levels.

Research on Polyphenols

Fisetin, like other polyphenols such as resveratrol, is a sirtuin-activating compound and has been shown in laboratory studies to extend the life of simple organisms like yeast, worms, and flies.^[12] Like the other compounds, it has also been shown to be reactive in many different assays of biological activities, raising the possibility that any drug generated from fisetin would have too many side effects to be useful.^[12][13]

Fisetin has shown anti-cancer activity in studies on cells and model animals conducted in laboratories, and appears to block the PI3K/AKT/mTOR pathway.^[14] In lab studies it also has been shown to be an anti-proliferative agent, interfering with the cell cycle in several ways.^[15]  Fisetin, like some other flavonoids, has been found in lab studies to be a topoisomerase inhibitor, which may turn out to be a carcinogenic activity or an anti-cancer activity – further research is needed.^[16]

Fisetin has been shown to be an effective senolytic agent in wild-type mice, with effects of increased lifespan, reduced senescence markers in tissues, and reduced age-related pathologies.^[17] A clinical trial in the U.S. is currently underway as of October 2018 to show effectiveness in humans.^[18]

In studies conducted on cells in a laboratory, fisetin inhibits the activity of several pro-inflammatory cytokines, including tumor necrosis factor alpha, interleukin 6, and Nuclear factor kappa B.^[15] It has also been shown in lab studies to upregulate glutathione, an endogenous antioxidant.^[15][19] Fisetin also has direct activity as a reducing agent, chemically reacting with reactive oxygen species to neutralize them.^[19] Based on lab studies, it appears that fisetin lodges in cell membranes and prevents oxidative damage to lipids in the cell membrane.^[19] Fisetin, like other flavonoids, has a planar structure, with multiple carbon rings. Fisetin is able to scavenge free radicals as a result of its electron donating capacity, which is due to the presence of two hydroxyl groups on one ring and a hydroxyl group on another ring.^[19]

In vitro screening has identified fisetin as an antimitotic compound.^[20]

Video's on NAD+

Our Technology

Dr. Lieurance worked toward creating a better NAD+ delivery.  Shortly after pioneering the Nasal Delivery in 2018, he began working on way to make NAD+ stable in a suppository, thus NeuroNAD™ Suppository was born. NeuroNAD™ Suppository combines ABC’s SRT™ Slow Release Technology along with Nano Lipospheric Technology NLT NAD+™. Both NeuroNAD™ products are a highly efficient way to boost NAD+ into he body and can be used together for maximum effect to raise levels.

Sustained-release technology is ABC’s suppositories are of benefit, due to increased bioavailability. ABC has found that the addition of SRT improved the bioavailability of glutathione by 30% compared to the suppositories without SRT. These absorptions were improved enormously by the addition of a proprietary and natural polypeptide. Excellent prolonged absorption and high bioavailability were obtained, exhibiting both high plasma level and prolonged absorption. Our research shows that ABC’s preparations containing SRT may be superior in a rectal preparation, with prolonged action and giving a high plasma level, compared to standard suppository bases without ABC’s SRT!

Why do we use probiotics in our suppositories?

APO-808 is a proprietary blend of probiotic strains that is unique to our suppository technology. ABC has discovered certain bacteria strain combination of probiotics can support the absorption and utilization, when combined with various ingredients. Probiotics are beneficial bacteria that exist in our large intestine, called the microbiome, which is exactly where the suppository is absorbed. Using probiotics via suppository makes for a unique route of delivery, as it bypasses the acid in the stomach that normally destroys most probiotics taken orally. In addition, it has been clinically shown that oral probiotics may not even colonize your gut at all. Due to the need for the probiotics to be incorporated into the gut wall, research has shown we might be wasting our money taking most probiotics orally.  ABC’s probiotic strains have been combined with our special suppository base, which consists of organic palm oil. This combination rests on the gut wall over a 5-8 hour period to allow for the incorporation and colonization of the bacteria in the large intestines. Besides the unique delivery of the probiotics via suppository route, it has been scientifically shown that many nutrients are brought into the bloodstream by various strains of beneficial flora in your microbiome. The scientists at ABC have isolated various combination of flora that work specifically with the nutrients it is combined with.

APO-808 is designed to work with Glutathione in particular to down regulate the inflammation through normalizing the gut microbiome as well as allowing maximum absorption of Glutathione. The strains contained in the APO-808 Blend have been shown in the research to support healthy inflammation and immune function.

Resveracel Oral NAD+ Precursor.

Supports healthy aging*

ResveraCel combines nicotinamide riboside with resveratrol and cofactors to support healthy aging.* It provides support for metabolic syndrome and increase cellular energy production.*

ResveraCel® Details

Why Suppositories?

Many folks are uneasy with even mentioning of rectal suppositories until they realize how very powerful this approach can prove to be.  For some, navigating around this phobia could make the difference between health and sickness, or enhanced performance for those biohackers!

There is a growing acknowledgement of the need to provide safer, more cost-effective treatments that can either reduce the need for pharmaceuticals (ie: drugs) and/or to reduce their side effects. There is a mountain of research to demonstrate vitamins, extracts, nutrients, herbals and nutraceuticals can do just that, if only they could be absorbed in such a manner as to allow greater therapeutic effect.

How do Rectal Suppositories Work?

Everything, when administered orally, is absorbed from the gastrointestinal tract into the portal venous circulation and pass through the liver (first pass metabolism), where the process of metabolism or breakdown begins. Suppositories, like intravenous (IV), intramuscular (IM), and transdermal methods of administration, bypass this “first pass” effect and are absorbed into the rectal veins, without encountering liver metabolism. Fortunately, the rectum is filled with blood vessels that offer direct access into the body’s bloodstream. This allows for rapid access to systemic circulation.

When nutrients are put into our special suppository base they are protected and delivered through Slow Release Technology along with the support of the probiotics APO-808. Glutagenic’s™’s proprietary suppository base is formulated with ingredients that promote the movement of the active nutrients from the base to the rectum.  This technology facilitates solubility, and allows a compound that is usually insoluble in water (hydrophobic) to dissolve, and thus be absorbed. This is crucial for poorly absorbed compounds.

ABC’s suppositories are easy to insert, non-irritating, rapid-melting, fully absorbed in 5-10 minutes, and you’ll not know its in there after insertion.

Terpene Profile

Terpenes: These are the NON psychoactive components in cannabis. They are the fragrant essence of ALL essential oils! They give plants their unique smell and they also hold the healing benefits within the plants. Terpenes have been studied extensively and they are at the forefront of interest of the pharmaceutical companies, due to the unique and safe profile they can have. Terpenes that are specifically shown to reduce pain, are anti inflammatory and reduce anxiety have been incorporated into NeuroDiol™.* These terpenes also have been shown to improve CBD and other cannabinoids utilization and uptake into the brain.*

Myrcene: is a terpene that occurs often in highly fragrant plants and herbs such as mangoes, hops, bay laurel leaves, thyme, lemongrass, and basil. Myrcene is produced by numerous cannabis strains, and some rodent-model studies have suggested that it might lend sedative effects. Main effects are Anti-inflammatory, Analgesic (pain relief), Antibiotic and Mood Elevation.*

Another place you’ll find myrcene is in mangoes. Anecdotal evidence suggests that eating a ripe mango prior to consuming cannabis, may accentuate or extend the effects of cannabinoids. Some have suggested that this is due to the fruit’s concentrations of myrcene, which is naturally synergistic with CBD and allows cannabinoids to more easily bridge the blood-brain barrier.

Limonene: is an aromatic cannabis terpene produced in the flower’s resin glands. In isolation, it’s commonly associated with fruity and citrus aromas. Inhalation of limonene vapor increases serotonin and dopamine levels in key regions of the brain that are associated with anxiety, depression, and OCD. Limonene’s potential therapeutic benefits have shown potential in the following applications: Elevated mood*, Stress relief*, Antifungal properties*, Antibacterial properties*, May help relieve heartburn and gastric reflux*, Improves absorption of other terpenes and chemicals by way of the skin, mucous membranes, and digestive tract* (Ref)

Alpha & Beta Pinene, as you might have guess it, has a strong scent of pine. Commonly found in conifer trees, parsley, dill, basil, and rosemary, alpha-pinene is easy to detect.

A study in 2012 showed that alpha-pinene was a potent anti-inflammatory agent against Acute Pancreatitis, an inflammatory disease with an unknown cause. A study in 2011 showed that alpha-pinene, along with all the different cannabinoids and terpenes found in cannabis, interact synergistically and amplify anti-inflammatory activity. These results show that alpha-pinene supports lower inflammation management for diseases such as arthritis, Crohn’s, and multiple sclerosis.*

Both alpha-pinene and beta-pinene proved to be effective antimicrobial agents against bacterial and fungal cells. In 2011, alpha-pinene was tested as a potent treatment against a bronchitis virus that was previously hard to treat since antibiotics don’t work on viruses. Although not effective against all bacteria and viruses, alpha-pinene was shown in research to support the immune system in a wide range of these infectious diseases. More studies need to be performed to assess the effectiveness of alpha-pinene on all bacteria. (Ref)

Bronchodilator: In a 2011 study, alpha-pinene showed promise as a bronchodilator, by opening up the upper respiratory tract (at low exposure levels), which can be helpful for people with asthma.

Memory: We’ve all heard of the forgetful stoner stereotype. The cannabinoid tetrahydrocannabinol (THC) plays a part in decreasing short-term memory attention. The alpha-pinene terpene, however, has been shown to counteract these memory impairing effects. Alpha-pinene plays a strong role in inhibiting acetylcholinesterase activity in the brain, which helps you retain memories more efficiently. (Ref)

Alpha Phellandrene: This terpene smells herbaceous, citrusy, minty, peppery, and a little woodsy. The next time you smell mint leaves or a lavender candle, appreciate the Alpha Phellandrene terpene smell!

Anti-depressive & Analgesic Actions of limonene, α-Phellandrene, and in a Neuropathic Pain Model (Ref)

Alpha–phellandrene significantly inhibited the production of the pro-inflammatory cytokines TNF-α and IL-6. Alpha–phellandrene Promotes Immune Responses in Normal Mice Through Enhancing Macrophage Phagocytosis and Natural Killer Cell Activities.  (Ref)

Alpha–phellandrene has modulating effect on neutrophil migration and mast cell degranulation processes. (Ref)

Boswellia: or Indian Frankincense, is a resin herbal extract from the boswellia tree, which natural medicine practices have used for centuries. Its anti-inflammatory effects mean that it may help with inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and asthma. We included this amazing extract into our products due to all of the positive healing properties

Linalool: is a naturally occurring terpene found in many flowers and spices including lavender and coriander. It gives off a complex yet delicate floral aroma, and while its effects are myriad, it is in particular one of the substances used most widely to reduce stress. Humans have inhaled the scent of certain plants, including many containing linalool, since ancient times to help lower stress levels, fight inflammation, and combat depression.* Linalool has been the subject of many studies, including a recent one in which scientists allowed lab rats to inhale linalool, while exposing them to stressful conditions. It was reported that linalool returned elevated stress levels in the immune system to near-normal conditions. Linalool’s Effects and Benefits include anti-anxiety, Anti-depressant, Mood Elevation, Anti-inflammatory, Anti-epileptic and Analgesic.* (Ref)

Dosage and Storage

Dosage and Storage Instructions: Wash your hands thoroughly with soap and water. Keep the suppository in the refrigerator so it remains hard before removing the wrapper. Put on a finger cot or disposable glove, if desired (available at a pharmacy). Lubricate the suppository with a water soluble lubricant such as K-Y Jelly or coconut oil, not petroleum jelly (Vaseline). If you do not have this lubricant, moisten your rectal area with cool tap water. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Insert the suppository, pointed end first, with your finger until it passes the muscular sphincter of the rectum, about ½ to 1 inch in infants and 1 inch in adults (If not inserted past this sphincter, the suppository may pop out). Hold buttocks together for a few seconds. Remain lying down for about 5 minutes to avoid having the suppository come out. Discard used materials and wash your hands thoroughly.

Suggested dosage is 1 (one) suppository daily or 3 times a week. Depending on your daily schedule. NeuroNAD™ Suppository should be taken at night before bed and NeuroNAD™ Nasal Spray should be taken during the daytime (1-4 times) for an effective boost into the brain where is is most needed!

Store this product in a refrigerated climate. Keep this product away from sunlight. Please use the product within six months of purchase date for best results.

Disclaimer, Disclosure and Lab Testing

FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE

The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent disease or medical conditions. The products and information found on Glutagenic.com are not intended to replace professional medical advice or treatment. Individual results may vary. Glutagenic urges you to seek the advice of a qualified professional for any health concern, and to share with your provider any information pertaining to your health and well-being, including the use of supplemental nutrition. We try our best not to make mistakes; however, if typographical errors appear in our site, we cannot be held responsible. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other complications before using any product. The Federal Food, Drug, and Cosmetic Act require this notice.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.