Lucitol Ultra™ is a product that was developed with much excitement and care, to make sure the blend was perfect. We spent many months working with various plant polyphenols from the flavonoid group.  Lucitol Ultra™  is designed to provide the cleanest and most complete absorption of these key nutrients. This all star line up of Fisetin (Read my article here) Resveratrol, Ginkgo B.,Pterostilbene, EGCG, Lutein, Quercetin & Curcumin are all in the Lucitol Ultra™. Also, see NADMax Ultra™. Fasting is also a great way to clean up cellular senescence! Lucitol Ultra™ can be taken safely during a fast, as well as after using NAD+ Products, to minimize senescent survivability. See Mito Fast Protocol here. Polyphenols such as Fisetin & Curcumin are poorly absorbed through oral ingestion. Liposomes offer a valuable means to receive the most potent and fullest potential of these nutrients.

Liposomal Delivery

Liposomal delivery systems, with their advanced nutrient bioavailability, are becoming more popular. There are over 65,000 peer-reviewed published studies on Liposomal delivery. They are utilized in medicine for the delivery of vaccines, hormones, enzymes, vitamins, and botanicals.

Liposomes are tiny lipid bubbles about the width of a single human hair. They are made out of the same type of fat as our cell membranes, phospholipids. Liposomes are stable and can carry both water and fat-soluble nutrients. When formulated correctly, they can facilitate absorption as soon as they land on the tongue, and can help protect against breakdown by digestive acids, and enzymes and the first pass through the liver. Because they are made of the same lipids that compose our cell membranes, they may assist nutrients to gain access to the cell membrane and optimize cellular support.

Liposomal technology, like a bullet, has been said to provide the power of intravenous therapy. Because of enhanced delivery and absorption, nutrients delivered in the liposomal form at lower doses may offer equal or greater efficacy than higher doses provided in less bioavailable forms.[8]^,[9]

Their potency is impressive. In liposomal form, the absorption of glutathione can compare to that of intravenous formulations, and appears to help maintain intracellular storage.[10]^,[11] Even better, the phospholipids in liposomes are therapeutic. They help nourish every cell membrane by providing the lipids needed to function optimally and flush out toxins that accumulate there.

Advanced Ultra-Nano Liposomal Formulations Are More Effective

Not all liposomes are alike. The technology used to manufacture them, as well as their size, can vary considerably.

Liposomes are emulsions, but not all emulsions can become liposomes.   Liposomes are specific ‘vesicles’ or bubbles modified to carry either fat-soluble or water-soluble molecules. Their likeness to living bi-layer lipid cell membranes is remarkable. If a vitamin or nutrient is placed inside the liposome, it will not readily pass through the bilayer. When the liposome merges with the lipid bilayer of the cell membrane, it can deliver its contents directly to the cell.

The size of a liposome—smaller sizes have been shown to offer dramatically higher uptake such as with our Ultra-Nano. That’s because the tiniest vesicles can be dramatically more efficient at cellular delivery of encapsulated nutraceuticals. In one notable study, cellular uptake increased 9-fold as liposome size dropped from 236 nm to 97 nm. At the smallest size of 64 nm, the uptake was 34-fold higher.[13]

Beyond Liposomes: Ultra-Nano 

Particles at this incredibly tiny size are so small that they are even smaller than wavelengths of visible light. They are crafted using modern technology and high-level equipment.

References

[1]Olthof MR, Hollman PC, et al. Bioavailabilities of quercetin-3-glucoside and quercetin-4′-glucoside do not differ in humans. J Nutr, 2000 May;130(5):1200-3. View Abstract

[2]Seeram NP, Lee R, Heber D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta, 2004 Oct;348(1-2):63-8. View Abstract

[3]Manach C, Williamson G, Morand C, et al. Bioavailability and bioefficacy of polyphenols in humans. Review of 97 bioavailability studies. Am J Clin Nutr, 2005 Jan;81(1 Suppl):230S-42S. View Abstract

[4]Xu JZ, Yeung SY, Chang Q, et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br J Nutr, 2004 Jun;91(6):873-81. View Abstract

[5]Nieves CJ, Montero C, et al. Bioavailability of Herbs and Spices. The FASEB Journal 2009;23:1_supplement, 718.13 View Abstract

[6]Emami S, Azadmard-Damirchi S et al. Liposomes as carrier vehicles for functional compounds in the food sector, Journal of Experimental Nanoscience. 2016.11:9, 737-759. View Full Paper

[7] Taylor TM, Weiss J, et al. Liposomal nanocapsules in food science and agriculture. Crit Rev Food Sci Nutr. 2005;45:587–605 View Full Paper

[8]Silva AC, Santos D, et al. Lipid-based nanocarriers as an alternative for oral delivery of poorly water-soluble drugs: Peroral and mucosal routes. Curr Med Chem. 2012;19(26):4495-4510. View Abstract

[9]Rogers JA, Anderson KE. The potential of liposomes in oral drug delivery. Crit Rev Ther Drug Carrier Syst. 1998;15(5):421-480. View Abstract

[10]Levitskaia TG, Morris JE. Aminothiol receptors for decorporation of intravenously administered (60)Co in the rat. Health Phys. 2010 Jan;98(1):53-60. View Full Paper

[11]Zeevalk GD, Bernard LP Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells.  Neurochem Res. 2010 Oct;35(10):1575-87. View Abstract

[12] Unpublished study on Caco-2 intestinal cells by Quicksilver Scientific,

[13] Hood RR, Andar A, et al. Pharmacy-on-a-chip: Microfluidic synthesis of pegylated and folate receptor-targeted liposomes for drug delivery. 16^th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2012. Okinawa, Japan.

[14]Alexander-Bryant AA, Wen X. Bioengineering Strategies for Designing Targeted Cancer Therapies. In: Advances in Cancer Research, 2013 View Abstract

[15]Smith ME, Morton DG.  Digestion And Absorption. In: The Digestive System (Second Edition), 2010

[16] Bawa R. Nanoparticle-based therapeutics in humans: A Survey. Nanotech L&B ,2008;5 : 135–155

[17]Kedar U et al. Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine, 6 (6) (2010), pp. 714-729

[18]Shoji Y, Nakashima H. Nutraceutics and delivery systems. J Drug Target, 2004;12(6):385-91.

Supplement Fact

Dosage and Storage Instructions: Suggested dosage is 1 (one) bullet daily or 3 times a week. Depending on your daily schedule. Consider taking Lucitol™ during and after fasting as well as when taking NAD+ Products to minimize senescent survivability.

The product is intended for oral use. Store this product in a refrigerated climate. Keep this product away from sunlight. Please use the product within six months of the purchase date for the best results.

Supplement Ingredients:

Serving size: 1                                                Serving: 12                             Amount Per Serving                                   % Daily Value

Proprietary Blend:

Fisetin, Pterostilbene                                                *****

Ginkgo B., EGCG, Lutein                                          *****

Quercetin, Curcumin.                                               *****

Resveratrol                                                                     *****

Limonene                                                                       *****

Organic Orange & Vanilla Essential Oil             *****

SRT Polysaccharide Complex.                               *****

Organic Sunflower Lecithin.                                  *****.  

Stevia, Erythritol.                                                      *****

             ****Daily Value not established****

Research

Some of the most exciting studies on these polyphenols in neurology, as well as  (senolytic/autophagy)  address microglial activation. Read my article on Fisetin here. See the amazing studies on Fisetin (Ref)  you will see why many are looking at these nutrients as the father of all anti-aging substances. Take a close look at Micro Glial activation as well as Cellular senescence to fully appreciate Lucitol™ (Ref). Senescent cells accumulate with age! Senescent cells are cells that go into a permanent state of sleep like a zombie and continue to consume energy and produce lots of oxidation! Senescent cells secrete pro-inflammatory chemicals from something scientists call SASP (senescence-associated secretory phenotype). The SASPs are thought to significantly contribute to aging! (Ref) Analytics that remove SASP is a great strategy for promoting health and longevity. Poor energy levels at a cellular level are a headwind for the body to properly clear out these zombie cells. Mitochondria, the powerhouse of the cell, is a key component of this cellular energy. Both NAD+ as well as mitochondria health decline with age.  Fisetin, Resveratrol, Ginkgo B., EGCG, Lutein, Quercetin & Curcumin are all heavily researched. Also, Fasting is a great way to clean up cellular senescence! Freund, A., Orjalo, A. V., Desprez, P. Y., & Campisi, J. (2010). Inflammatory networks during cellular senescence: causes and consequences. Trends in molecular medicine, 16(5), 238-246. [4] Coppé, J. P., Desprez, P. Y., Krtolica, A., & Campisi, J. (2010). The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual review of pathology, 5, 99. Fisetin, like other polyphenols such as resveratrol, is a sirtuin-activating compound and has been shown in laboratory studies to extend the life of simple organisms like yeast, worms, and flies.^[1] Like the other compounds, it has also been shown to be reactive in many different arrays of biological activities, raising the possibility that any drug generated from fisetin would have too many side effects to be useful.^[1][2] Fisetin has shown anti-cancer activity in studies on cells and model animals conducted in laboratories and appears to block the PI3K/AKT/mTOR pathway. In lab studies it also is an anti-proliferative agent, interfering with the cell cycle in several ways. Fisetin, like some other flavonoids, has been found in lab studies to be a topoisomerase inhibitor, which may turn out to be a carcinogenic activity or an anti-cancer activity – further research is needed.^[6] Fisetin is an effective senolytic agent in wild-type mice, with effects of increased lifespan, reduced senescence markers in tissues, and reduced age-related pathologies.^[7] A clinical trial in the U.S. is currently underway as of October 2018 to show effectiveness in humans.^[8] In studies conducted on cells in a laboratory, fisetin inhibits the activity of several pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin 6, and Nuclear factor kappa B.^[5] It has also been shown in lab studies to upregulate glutathione, an endogenous antioxidant.^[5][9] Fisetin also has direct activity as a reducing agent, chemically reacting with reactive oxygen species to neutralize them.^[9] Based on lab studies, it appears that fisetin lodges in cell membranes and prevent oxidative damage to lipids in the cell membrane.^[9] Fisetin, like other flavonoids, has a planar structure, with multiple carbon rings. Fisetin can scavenge free radicals as a result of its electron-donating capacity, which is due to the presence of two hydroxyl groups on one ring and a hydroxyl group on another ring.^[9]  

Disclosures and Disclaimers

WARNINGS: Although safe for children, this product should be kept out of the reach of children. Do not use it if the package is open or damaged. As with any nutrient, if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Please know that this product can be taken safely by mouth. It is a dietary supplement by current FDA guidelines.

FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act-compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals, and amino acids products legally sold in the USA.  By FDA regulations, oral use is a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). MitoZen’s product line is a naturally derived FDA GRAS (Generally regarded As Safe) mineral, herbal, vitamins, and nutraceutical products that can be legally sold in the USA. ABC’s products are not a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). MitoZen’s products are not intended to affect the structure or function of the body and are not intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure, or prevent disease nor should any information provided be used as a  substitute for sound medical advice. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use, if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are the property of their respective owners, and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. By using this site you agree to follow the Privacy Policy and Terms & Conditions printed on this site. Void Where Prohibited By Law.