Research Under Review

Scientific understanding of hemp, terpenes, and cannabinoids continues to evolve. Historically, many studies used small sample sizes, limiting the strength of their conclusions. As the volume of research grows and larger, well-controlled studies emerge, reviewers are now able to perform systematic reviews and meta-analyses that offer deeper insight into the efficacy and mechanisms of cannabis-derived compounds — especially terpenes.

Rather than conducting new experiments, review studies compile and analyze data from previously published, peer-reviewed research. This approach allows researchers to work with a broader dataset and draw more confident conclusions regarding therapeutic potential and safety.

Among the most compelling areas of investigation is the neurological impact of cannabinoids and terpenes. Evidence increasingly supports that certain compounds in hemp and cannabis may support brain health, offering neuroprotective effects and calming influence on the central nervous system — with notable implications for epilepsy, neuroinflammation, and cognitive decline.

As regulations ease globally and cannabis-based pharmaceuticals enter the mainstream, researchers are delving deeper into the molecular mechanisms behind these effects.

Highlighted Research

1. The Experiments Revealing How Marijuana Could Treat Dementia — review of preclinical research on THC and neurodegeneration. Discover Magazine
2. Urits, I. et al. (2019). An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine. Current Pain and Headache Reports, 23(10): 64. PubMed
3. Chesney, E. et al. (2020). Update on Cannabidiol Clinical Toxicity and Adverse Effects. CNS Drugs, 34(10): 997–1019. EurekaSelect
4. Crippa, J. et al. (2023). Cannabidiol and Brain Function: Current Knowledge and Perspectives. Frontiers in Pharmacology, 14:1328885. Frontiers

Franco, V. & Perucca, E. (2015). Cannabinoids and Epilepsy. Neurotherapeutics, 12(4): 747–768. SpringerLink

Terpenes: Nature’s Intelligent Design

Terpenes are the non-psychoactive aromatic compounds found in cannabis and virtually all plants. They are the fragrant backbone of essential oils, responsible for the distinct scents of lavender, pine, citrus, and countless herbs. Beyond their aroma, terpenes play powerful biological and therapeutic roles, influencing mood, inflammation, and cellular communication.

At MitoZen, we incorporate clinically studied terpenes selected for their proven abilities to reduce pain, calm the nervous system, and enhance cannabinoid absorption and utilization—a synergy known as the entourage effect. These compounds help optimize the effectiveness of NeuroDiol™ and support whole-body balance.*

Key Terpenes in NeuroDiol™

Myrcene

Found in mangoes, hops, lemongrass, and basil, myrcene is one of the most abundant terpenes in cannabis. It is known for its anti-inflammatory, analgesic, and sedative effects.* Research suggests myrcene enhances the blood–brain barrier permeability, improving the uptake of cannabinoids for amplified therapeutic benefits.*

Linalool

A major component of lavender and coriander, linalool is renowned for its stress-reducing, anti-anxiety, and neuroprotective properties.* Studies demonstrate that linalool inhalation can restore normal immune response under stress, highlighting its potential to balance mood and inflammation.*

Limonene

This citrus-derived terpene contributes to feelings of alertness and elevated mood.* Research links limonene to increased serotonin and dopamine activity, suggesting benefits for anxiety, depression, and cognitive clarity.* It also exhibits antimicrobial, antifungal, and digestive-supportive actions, while improving the bioavailability of other compounds.*

Emerging studies indicate anti-tumor potential, particularly in breast and skin cancer models, through mechanisms that may inhibit tumor growth and promote apoptosis (cell death).*

Alpha & Beta Pinene

Responsible for the crisp scent of pine and rosemary, pinene offers a wide spectrum of therapeutic effects, including anti-inflammatory, antimicrobial, and bronchodilating properties.* It has also been shown to counteract short-term memory impairment sometimes associated with THC by preserving acetylcholine activity in the brain.*

Alpha-Phellandrene

Recognized for its minty, citrus-herbal aroma, alpha-phellandrene supports immune health by enhancing macrophage and natural killer cell activity.* Widely used in natural wellness and aromatherapy, this terpene contributes to energy, comfort, and mental clarity while providing gentle soothing and uplifting effects.*

Synergy and Function

Together, these terpenes form a neuro-supportive matrix that complements the cannabinoids in NeuroDiol™. Their combined effects may:

• Enhance cannabinoid bioavailability and transport across the blood–brain barrier*
• Support *anti-inflammatory and neuroprotective pathways
• Promote *calm focus, mood balance, and resilience to stress
• Encourage cellular health and mitochondrial function*

This is the science of synergy—where plant intelligence and human innovation meet to optimize your body’s natural healing systems.

Suggested Use

Begin with 20–25 mg daily. Using the dropper, place the desired amount under your tongue and hold for 30–90 seconds before swallowing to enhance absorption.

Alternatively, you may mix the product with food or a beverage if preferred.

Adjust your dosage gradually, increasing weekly based on your individual response.

Higher daily amounts may offer additional support for sleep, stress, or discomfort, with advanced protocols ranging from 100–300 mg per day under professional guidance.

For oral use only. Store in a cool, dry place, away from direct sunlight.

Use within six months of purchase, and maintain a consistent routine for optimal results.