Solace™-Corydalis-Curcumin Bullet

Solace™ was developed with care and precision to achieve the perfect synergy between natural relaxation and liver support. After months of formulation and testing, we optimized extracts from the Corydalis Yanhusuo stem—renowned for its calming and analgesic properties—and combined them with Curcumin to help protect and support liver health during use.

This advanced formula also features a targeted terpene profile of Myrcene, Linalool, and Humulene, along with our proprietary AP0-808™ Probiotic Blend and SRT™ Polysaccharide Complex for enhanced absorption and sustained release. The result is a sophisticated botanical supplement that promotes relaxation, comfort, and balanced wellbeing.

Precautions Before Use

While Corydalis Yanhusuo has a long history of traditional use, modern research on its interactions with other herbs, supplements, and medications remains limited. Please consult your healthcare provider before beginning Solace™, especially if you are taking prescription or over-the-counter medications.

This product is not recommended for children, pregnant or breastfeeding individuals, or those with a history of seizures.

Short-term use (up to 4 weeks) is considered safe for most adults, but extended use should be discussed with your healthcare provider.

Corydalis contains the alkaloid THP (tetrahydropalmatine), which may cause liver stress in excessive doses. Animal studies indicate toxicity only at extremely high concentrations (approximately 475mg/kg body weight), whereas each serving of Solace™ contains a carefully controlled 100mg of THP—a fraction of that amount. Symptoms of liver stress may include nausea, vomiting, abdominal discomfort, or fever. Discontinue use and consult a physician if these occur.

Solace™ is formulated for short-term use of less than four weeks to support comfort and relaxation safely and effectively.

[1] Wu et al. (2021) Processing and Compatibility of Corydalis yanhusuo: Phytochemistry, Pharmacology, Pharmacokinetics, and Safety, Evid-Based Complementary and Alternative Medicine. doi:10.1155/2021/1271953 https://doi.org/10.1155/2021/1271953

The Research Behind Corydalis Yanhusuo

Modern studies have confirmed that Corydalis Yanhusuo contains a range of active alkaloids—most notably dl-tetrahydropalmatine (THP)—which exert measurable effects on the central nervous system.

Pain and Nerve Support:
Research indicates that THP may be effective in reducing nerve-related pain. In a preliminary study, 75 mg per day of THP reduced nerve discomfort in 78% of participants. [1]
Sleep and Relaxation:
Clinical observations show that individuals taking 100–200 mg/day of a Corydalis extract (dl-THP) experienced improved sleep quality and easier onset of rest—without grogginess or next-day dizziness. [2]
Cardiovascular Support:
In a small trial, THP demonstrated anti-arrhythmic activity, showing benefit for patients with supraventricular premature beats (SVPB). [3]
Digestive Comfort:
Corydalis extract has shown positive results in reducing stomach and intestinal discomfort associated with ulcers and chronic gastritis. [4]

Safety & Liver Support

While Corydalis Yanhusuo is generally well tolerated at moderate doses, high concentrations of total alkaloids have shown mild liver stress in animal studies. [5]

To support balance and safety, Solace™ includes Curcumin, which research shows can help mitigate potential hepatotoxicity of Corydalis alkaloids. [6]

References

The Analgesic Properties of Corydalis yanhusuo. Front Pharmacol. 2021. PMC8704877
Preliminary clinical report on THP and insomnia outcomes (summarized in Wu et al., 2021, Evid-Based Complement Altern Med. 10.1155/2021/1271953)
Preliminary trial on dl-THP and supraventricular premature beat (SVPB) patients.
Clinical use of Corydalis yanhusuo for gastrointestinal comfort, summarized in secondary literature.
Wu L. et al. (2021). Processing and Compatibility of Corydalis yanhusuo: Phytochemistry, Pharmacology, Pharmacokinetics, and Safety. Evid-Based Complement Altern Med. 10.1155/2021/1271953
Ibid — Hepatotoxicity reduction with Curcuma longa (Curcumin) co-administration.

Serving size: 1 Bullet	Servings: 15
Amount Per serving	% Daily Value
Proprietary Blend	****
Corydalis Extract containing 98% THP	100mg
Hemp / Full Spectrum	20mg
Curcumin / Boswellia	****
Terpenes: Myrcene, Linalool, Humulene	****
AP0-808 Probiotic Blend	****
SRT Polysaccharide Complex.	****
Organic Palm Oil	****
**Daily Value not established**

WARNINGS: Although safe for children, this product should be kept out of the reach of children. Do not use it if the package is open or damaged. As with any nutrient, if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

This product can be taken safely by mouth. According to FDA regulations this product is considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Disclaimer: These statements have not been evaluated by the FDA. In accordance with FDA regulations, this product can be taken orally, this product and is considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).This product is a Federal Food, Drug, and Cosmetic Act-compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals, and amino acids products legally sold in the USA. According to FDA regulations this product is considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). MitoZen PMA’s product line is a naturally derived FDA GRAS (Generally regarded As Safe) mineral, herbal, vitamins, and nutraceutical products that can be legally sold in the USA. MitoZen PMA products are not a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). MitoZen’s products are not intended to affect the structure or function of the body and are not intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure, or prevent disease nor should any information provided be used as a substitute for sound medical advice. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use, if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are the property of their respective owners, and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. By using this site you agree to follow the Privacy Policy and Terms & Conditions printed on this site. Void Where Prohibited By Law.

COAs and Lab Testing

This product is a Federal Food, Drug, and Cosmetic Act–compliant formulation, composed of naturally derived ingredients classified by the FDA as GRAS (Generally Recognized As Safe), including select herbal extracts, nutraceuticals, vitamins, minerals, and amino acids legally sold in the United States.

Under FDA regulations, oral use of this product qualifies as a dietary supplement as defined by Section 201(ff) of the Act (21 U.S.C. § 321(ff)).

MitoZen’s product line consists of naturally derived, FDA GRAS-certified mineral, herbal, vitamin, and nutraceutical formulations that may be legally marketed in the USA.

MitoZen products are not drugs as defined in Section 201(g)(1) of the Act (21 U.S.C. § 321(g)(1)), and they are not intended to affect the structure or function of the body, nor to diagnose, cure, mitigate, treat, or prevent any disease in humans.

Any nutritional information or research shared about this product is provided for educational and informational purposes only and should not replace professional medical advice or treatment.

This product is not for use by or for sale to individuals under 18 years of age.

Use only as directed on the label.

Do not use if you are pregnant or nursing.

Consult a qualified healthcare professional before use if you have a serious medical condition or are taking prescription medications.

Always seek a doctor’s advice before beginning any new dietary supplement regimen.

All trademarks and copyrights are the property of their respective owners and are not affiliated with, nor do they endorse, this product.

By using this site, you agree to abide by the Privacy Policy and Terms & Conditions posted herein.

Void where prohibited by law.

While generally safe, this product should always be kept out of the reach of children.

Do not use if the packaging is open or damaged.

As with any advanced nutrient supplement, if you are pregnant, breastfeeding, or taking medications, consult your healthcare professional before use.

Cold Shipping

To preserve the integrity and bioactivity of temperature-sensitive compounds, we recommend selecting the Cold Shipping option during warmer months. This ensures your product remains stable and arrives in optimal condition.

Shipping Disclaimer

To maintain strict quality control standards:

Orders requiring Cold Shipping placed on Thursday or Friday will be shipped the following Monday to prevent unnecessary transit time.
Orders placed over the weekend will also ship on Monday.

These measures are implemented to uphold the highest standards of product purity, potency, and stability from our lab to your door.

Pain Reduction

Sleep Support

Relaxation

Take 1–2 suppositories (“bullets”) every 4–6 hours as needed for comfort or relaxation.

Do not exceed 2 bullets per day, and limit continuous use to no longer than 4 weeks, unless otherwise directed by your healthcare provider.

This product can be taken orally. If your healthcare provider recommends rectal or vaginal administration, they are also safe and effective when used as directed.

This formulation contains 100 mg of THP, within a clinically safe range, and includes Curcumin to help support healthy liver function.

Important Safety Information

Not intended for use during pregnancy or while nursing.
Do not use if you have a history of seizures or are taking prescription medications without consulting your healthcare provider.
Not suitable for children.
Store refrigerated and protect from sunlight.
Use within 6 months of purchase for best results.
Read all product information before use.

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