NAD+Max™ Ultra + NeuroNAD™ Vertical Spray

The Ultimate NAD+ Replenishment Program

NAD+Max™ Ultra and NeuroNAD™ Vertical Spray can be used together for an even more powerful and synergistic NAD+ replenishment program. The heart and brain are the organs most sensitive to low NAD+ levels, and this dual approach delivers targeted support to both. These delivery routes—rectal and intranasal—are the most effective options available outside of IV therapy, which can cost between $500–$1,500 per session and requires 5–8 hours per treatment.

NAD+Max™ Ultra can be taken any time of day for systemic NAD+ support, while NeuroNAD™ Vertical Spray is best used during the daytime—1 to 4 times daily—for direct NAD+ delivery into the brain where it’s needed most.

This powerful combination forms the foundation of the NAD+Max Refuel Program, designed to restore and maintain optimal NAD+ levels. For enhanced results, pairing NAD+ replenishment with fasting protocols supports cellular cleanup by promoting the autophagy of senescent (“zombie”) cells.

Suggested 90-Day NAD+ Replenishment Protocol

Morning (2–5 consecutive days per week):

• Take NAD+Max™ Ultra upon waking.
• Best results are seen when paired with intermittent fasting (skipping breakfast), but fasting is not required.

Daytime (daily):

• Use NeuroNAD™ Vertical Spray 2–3 times per day, applying 2 sprays per nostril per use.
• Can be taken with or without food.

Follow-Up (1–2 days per week):

• Take Lucitol™ to help clear senescent cells and support detoxification pathways following NAD+ administration.

Additional Tip:

Combining NAD+ replenishment with fasting not only boosts mitochondrial energy production but also promotes cellular renewal, supporting long-term vitality, brain health, and healthy aging.

What is NAD+?

Nicotinamide Adenine Dinucleotide (NAD+) is a metabolic coenzyme found in every cell of the body. It plays a vital role in energy production, mitochondrial function, DNA repair, gene expression, and neurotransmitter regulation. Essentially, NAD+ is the spark that keeps your cells running efficiently and your brain functioning at its best.

Why Is NAD+ Important?

NAD+ is essential for cellular energy production and the regulation of critical biological processes. It serves two key purposes in the body:

1. Energy Conversion – NAD+ helps convert nutrients from food into usable cellular energy (ATP).
2. Cellular Regulation – NAD+ acts as a coenzyme for proteins that control DNA repair, gene expression, and cellular defense mechanisms.

Unfortunately, NAD+ levels naturally decline with age, leading to decreased mitochondrial efficiency, slower metabolism, cognitive decline, and signs of aging. Supporting and replenishing NAD+ levels can therefore play a major role in maintaining youthful energy, mental clarity, and cellular health.

The Power of NAD+

NAD+ is one of the most studied and essential molecules in biology. Found in all living organisms — humans, animals, yeast, and even plants — it’s involved in hundreds of metabolic reactions that sustain life.

Discovered over a century ago, NAD+ continues to be a focus of modern longevity and cellular health research. Scientists now recognize that maintaining optimal NAD+ levels is key to healthy aging, brain function, and resilience against cellular stress.

A Brief History of NAD+

The story of NAD+ began in 1906, when British biochemists Sir Arthur Harden and William John Young identified the molecule while studying yeast fermentation. In 1929, Harden shared the Nobel Prize in Chemistry with Hans von Euler-Chelpin, who uncovered NAD+’s role in metabolism and revealed that it was composed of two nucleotides — the same building blocks found in DNA.

Through the 1930s, Nobel laureate Otto Heinrich Warburg expanded on this work, describing NAD+ as essential for metabolic reactions. Around the same time, researchers discovered that nicotinic acid (vitamin B3), a precursor to NAD+, could prevent and treat pellagra, a deadly nutritional disease once common in the American South. This finding led to the fortification of foods with niacin — a landmark in nutritional science.

By the 1950s, scientists had mapped out the Preiss–Handler Pathway, demonstrating how dietary precursors like nicotinic acid are converted into NAD+ inside the body. This work earned widespread recognition and laid the foundation for modern NAD+ biochemistry.

The Science Advances

From the 1960s onward, researchers discovered the intricate cellular roles of NAD+, including its involvement in DNA repair through PARP (poly ADP-ribose polymerase) enzymes, and later, its activation of sirtuins, a class of proteins often called the “guardians of the genome.”

Sirtuins depend on NAD+ to maintain cellular balance (homeostasis), regulate metabolism, and protect against cellular stress. When NAD+ levels drop, sirtuin activity declines — leading to accelerated cellular aging.

MIT biologist Dr. Leonard Guarente and his colleagues were among the first to show that NAD+ directly activates sirtuins, linking energy metabolism to longevity pathways. Since then, thousands of studies have explored how preserving NAD+ levels may support healthy aging, brain health, energy, and resilience.

NAD+ Decline and Replenishment

The body cannot maintain an infinite supply of NAD+, and levels naturally decline with age, stress, and inflammation. While NAD+ precursors such as nicotinic acid, nicotinamide, and nicotinamide riboside (NR) exist in certain foods, oral absorption is limited, and much of it is lost during digestion.

This is why direct delivery methods—such as IV therapy, liposomal formulations, rectal delivery (NAD+Max™), or nasal administration (NeuroNAD™ Vertical Spray)—are preferred for effectively increasing NAD+ levels in the bloodstream and brain.

In Summary

NAD+ is an essential coenzyme that supports nearly every aspect of human health—from energy production and DNA repair to brain function and aging defense. Modern science continues to explore its vast therapeutic potential, with advanced delivery systems making it more bioavailable than ever before.

Suggested Use

Take NAD+Max™ Ultra in the morning upon waking, 2–5 consecutive days per week. It can be used with or without intermittent fasting; however, fasting may enhance its restorative effects.

For a complete NAD+ replenishment program, pair NAD+Max™ Ultra with NeuroNAD™ Vertical Spray, using 2–3 applications daily with two mists per dose.

For added support, Lucitol may be used on 1–2 days following NAD+ administration to help promote senescent cell clearance.

Consistent use over a 90-day protocol supports optimal heart, brain, and cellular NAD+ levels, helping maintain energy, focus, and long-term cellular vitality.